1-phosphatidylinositol 3-phosphate 5-kinase,5230400C17Rik,FYVE finger-containing phosphoinositide kinase,P,p235,phosphatidylinositol 3-phosphate 5-kinase type III,phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III,phosphatidylinositol-4-phosphate 5-kinase, type III,phosphoinositide kinase, FYVE finger containing,PIKfyve,Pip,Pip5k,Pip5k3,Pipk5k3,PipkIII,PIPkin-III,PtdIns(4)P-5-kinase,serine-protein kinase PIKFYVE,type III PIP kinase.
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole.
