CD10 Antibody - PE Conjugated, IgG2a, Clone: [B-E3], Mouse, Monoclonal
Artikelnummer:
ASB-OADB00005
Hersteller Artikelnummer:
OADB00005
Alternativnummer:
ASB-OADB00005-1ML
Hersteller:
Aviva
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
FC
Spezies Reaktivität:
Human
Konjugation:
PE
Alternative Synonym:
NEP, SFE, CD10, CALLA, CMT2T, SCA43
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5 untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.
