Purified CD271 protein isolated from human melanoma cell line A875
Konjugation:
RPE
Alternative Synonym:
CD271,Gp80-LNGFR,low affinity neurotrophin receptor p75NTR,low-affinity nerve growth factor receptor,NGF receptor,p75 ICD,p75(NTR),p75NTR,TNFR superfamily, member 16,TNFRSF16,tumor necrosis factor receptor superfamily member 16.
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
