DOK1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DOK1. The immunogen is located within amino acids 410 - 460 of DOK1.
Konjugation:
Unconjugated
Alternative Synonym:
docking protein 1,Downstream of tyrosine kinase 1,p240,p62(dok),P62DOK,p80 telomerase homolog,pp62,telomerase protein 1,telomerase protein component 1,TLP1,TP1,TROVE domain family, member 1,TROVE1,VAULT2.
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.