Bnip3L antibody was raised against a 16 amino acid peptide near the center of human Bnip3L. The immunogen is located within amino acids 60 - 110 of Bnip3L.
Konjugation:
Unconjugated
Alternative Synonym:
adenovirus E1B19k-binding protein B5,BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A,BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like,BCL2/adenovirus E1B 19-kd protein-interacting protein 3a,BCL2/adenovirus E1B 19kDa interacting protein 3 like,BNIP3a,NIP3L,NIP3-like protein X,NIP-3-like protein X,NIX.
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
