IKK gamma antibody was raised against a 17 amino acid peptide near the carboxy terminus of human IKK gamma. The immunogen is located within the last 50 amino acids of IKK gamma.
Konjugation:
Unconjugated
Alternative Synonym:
14.7K (adenovirus E3 protein) interacting protein 3,AMCBX1,EDAID1,FIP3,FIP-3,Fip3p,I-kappa-B kinase subunit gamma,ikB kinase subunit gamma,ikB kinase-associated protein 1,IKKAP1,IKKG,IKK-gamma,IMD33,incontinentia pigmenti,inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma,inhibitor of nuclear factor kappa B kinase subunit gamma,Inhibitor of nuclear factor kappa-B kinase subunit gamma,IP,IP1,IP2,IPD2,NEMO,NF-kappa-B essential modifier,NF-kappa-B essential modulator,ZC2HC9.
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either Lys-63-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response, this function requires Lys-27-linked polyubiquitination.
