TIRAP antibody was raised against a peptide corresponding to amino acids near the middle of human TIRAP. The immunogen is located within amino acids 80 - 130 of TIRAP.
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
