TICAM2 Antibody
Artikelnummer:
ASB-OAPB00211
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| Artikelname: | TICAM2 Antibody |
| Artikelnummer: | ASB-OAPB00211 |
| Hersteller Artikelnummer: | OAPB00211 |
| Alternativnummer: | ASB-OAPB00211-0.1MG |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | ELISA, ICC, IF, WB |
| Spezies Reaktivität: | Bovine, Human |
| Immunogen: | TIRP antibody was raised against a peptide corresponding to 16 amino acids at the C-terminus of human TIRP. The immunogen is located within the last 50 amino acids of TIRP. |
| Konjugation: | Unconjugated |
| Alternative Synonym: | cytoplasmic adaptor,MyD88-4,NF-kappa-B-activating protein 502,putative NF-kappa-B-activating protein 502,TICAM2,TICAM-2,TIR domain-containing adapter molecule 2,TIRAP3,TIRP,TMED7-TICAM2 read-through transcript,toll/interleukin-1 receptor (TIR) domain-containing adapter protein,Toll/interleukin-1 receptor domain-containing protein,toll-like receptor adaptor protein 3,TRAM,TRAM adaptor with GOLD domain,TRIF-related adapter molecule,TRIF-related adaptor molecule. |
| Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1, signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB, however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. |
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