GITRL antibody was raised against purified recombinant human GITR ligand.
Konjugation:
Unconjugated
Alternative Synonym:
activation-inducible TNF-related ligand,AITR ligand,AITRL,GITR ligand,GITRL,glucocorticoid-induced TNF-related ligand,glucocorticoid-induced TNFR-related protein ligand,hGITRL,TL6,TNLG2A,tumor necrosis factor (ligand) superfamily, member 18,tumor necrosis factor ligand 2A,tumor necrosis factor ligand superfamily member 18,tumor necrosis factor superfamily member 18.
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
