PEN2 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human PEN2. The immunogen is located within the last 50 amino acids of PEN2.
Konjugation:
Unconjugated
Alternative Synonym:
ACNINV2,gamma-secretase subunit PEN-2,hematopoietic stem/progenitor cells protein MDS033,MDS033,MSTP064,PEN2,PEN-2,presenilin enhancer 2 homolog,Presenilin enhancer protein 2.
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111).
