ARF-BP1 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human ARF-BP1. The immunogen is located within amino acids 4250 - 4300 of ARF-BP1.
Konjugation:
Unconjugated
Alternative Synonym:
ARF-binding protein 1,ARF-BP1,BJ-HCC-24 tumor antigen,E3 ubiquitin-protein ligase HUWE1,HECT domain protein LASU1,HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase,HECT, UBA and WWE domain-containing protein 1,HECTH9,HECT-type E3 ubiquitin transferase HUWE1,homologous to E6AP carboxyl terminus homologous protein 9,HSPC272,Ib772,large structure of UREB1,LASU1,Mcl-1 ubiquitin ligase E3,MRXST,MULE,upstream regulatory element-binding protein 1,UREB1,URE-B1,URE-binding protein 1.
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at Lys-41, Lys-61 and Lys-81, thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4.
