Human TRAIL Antibody : Biotin, IgG2b, Clone: [SB91a], Mouse, Monoclonal
Artikelnummer:
ASB-OASB01317
Hersteller Artikelnummer:
OASB01317
Alternativnummer:
ASB-OASB01317-0.5MG
Hersteller:
Aviva
Wirt:
Mouse
Kategorie:
Antikörper
Spezies Reaktivität:
Human
Immunogen:
Recombinant TRAIL
Konjugation:
Biotin
Alternative Synonym:
TL2, APO2L, CD253, TRAIL, Apo-2L, TNLG6A
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
