Synthesized peptide derived from human Rac GAP1 around the phosphorylation site of S387. Location: 330-410aa.
Alternative Synonym:
CYK4, ID-GAP, HsCYK-4, MgcRacGAP
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.
