Rspo1 High Sensitivity ELISA Kit (Mouse)
Artikelnummer:
ASB-OKCD01387
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| Artikelname: | Rspo1 High Sensitivity ELISA Kit (Mouse) |
| Artikelnummer: | ASB-OKCD01387 |
| Hersteller Artikelnummer: | OKCD01387 |
| Alternativnummer: | ASB-OKCD01387-96WELLS |
| Hersteller: | Aviva |
| Kategorie: | Kits/Assays |
| Applikation: | ELISA |
| Spezies Reaktivität: | Mouse |
| Alternative Synonym: | cristin-3,cysteine-rich and single thrombospondin domain-containing protein 3,mCristin-3,R,R-,roof plate-specific spondin-1,Rspondin,R-spondin,R-spondin homolog,R-spondin-1,thrombospondin type 1 domain containing gene Rspondin. |
| Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes (PubMed:21693646). Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination (By similarity). Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (By similarity). |
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