OLR1 ELISA Kit (Rabbit)
Artikelnummer:
ASB-OKCD01607
- Bilder (0)
| Artikelname: | OLR1 ELISA Kit (Rabbit) |
| Artikelnummer: | ASB-OKCD01607 |
| Hersteller Artikelnummer: | OKCD01607 |
| Alternativnummer: | ASB-OKCD01607-96WELLS |
| Hersteller: | Aviva |
| Kategorie: | Kits/Assays |
| Applikation: | ELISA |
| Spezies Reaktivität: | Rabbit |
| Alternative Synonym: | lectin-like oxidized LDL receptor 1,lectin-like oxLDL receptor 1,lectin-type oxidized LDL receptor 1,LOX1,LOX-1,oxidized low density lipoprotein (lectin-like) receptor 1,oxidized low-density lipoprotein receptor 1,ox-LDL receptor 1. |
| Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity). |
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