SUMO2 ELISA Kit (Human)
Artikelnummer:
ASB-OKCD01900
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| Artikelname: | SUMO2 ELISA Kit (Human) |
| Artikelnummer: | ASB-OKCD01900 |
| Hersteller Artikelnummer: | OKCD01900 |
| Alternativnummer: | ASB-OKCD01900-96WELLS |
| Hersteller: | Aviva |
| Kategorie: | Kits/Assays |
| Applikation: | ELISA |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | HSMT3,sentrin 2,Sentrin-2,small ubiquitin-related modifier 2,SMT3 homolog 2,SMT3 suppressor of mif two 3 homolog 2,Smt3A,SMT3B,SMT3H2,SUMO3,SUMO-3,ubiquitin-like protein SMT3A,ubiquitin-like protein SMT3B. |
| Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). |
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