exostoses (multiple) 1,exostosin-1,EXT,Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase,glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase,Langer-Giedion syndrome chromosome region,LGCR,LGS,multiple exostoses protein 1,N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase,putative tumor suppressor protein EXT1,TRPS2,TTV.
Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).