Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. recognizes and binds to the dna sequence 5-.taaa.a-3. participates in post-transcriptional regulation of myc: following phosphorylation by mapkapk5, promotes induction of mir-34b and mir-34c expression, 2 post-transcriptional regulators of myc that bind to the 3utr of myc transcript and prevent its translation.
