P4HB ELISA Kit (Human)
Artikelnummer:
ASB-OKCD07103
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| Artikelname: | P4HB ELISA Kit (Human) |
| Artikelnummer: | ASB-OKCD07103 |
| Hersteller Artikelnummer: | OKCD07103 |
| Alternativnummer: | ASB-OKCD07103-96WELLS |
| Hersteller: | Aviva |
| Kategorie: | Kits/Assays |
| Applikation: | ELISA |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | cellular thyroid hormone-binding protein,CLCRP1,collagen prolyl 4-hydroxylase beta,DSI,ERBA2L,GIT,glutathione-insulin transhydrogenase,P4Hbeta,p55,PDI,PDIA1,PHDB,PO4DB,PO4HB,procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide,PROHB,Prolyl 4-hydroxylase subunit beta,prolyl 4-hydroxylase, beta polypeptide,protein disulfide isomerase family A, member 1,protein disulfide isomerase/oxidoreductase,protein disulfide isomerase-associated 1,protein disulfide-isomerase,protocollagen hydroxylase,testicular secretory protein Li 32,thyroid hormone-binding protein p55. |
| This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9, the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). |
| Detektionsbereich: | 3.12-200pg/mL |
| Sensitivitaet: | < 0.114ng/mL |
| NCBI: | 5034 |
| Proben: | Serum, plasma, tissue homogenates and other biological fluids |
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