SETDB1 Recombinant Protein (Human)

Produktübersicht

• Artikelname: SETDB1 Recombinant Protein (Human)
• Artikelnummer: ASB-OPCA04793
• Hersteller Artikelnummer: OPCA04793
• Alternativnummer: ASB-OPCA04793-100UG, ASB-OPCA04793-1MG, ASB-OPCA04793-20UG
• Hersteller: Aviva
• Kategorie: Proteine/Peptide
• Spezies Reaktivität: Human
• Alternative Synonym: ERG-associated protein with a SET domain, ESET,ERG-associated protein with SET domain,ESET,H3-K9-HMTase4,histone H3-K9 methyltransferase 4,histone-lysine N-methyltransferase SETDB1,histone-lysine N-methyltransferase, H3lysine-9 specific 4,KG1T,KMT1E,lysine N-methyltransferase 1E,SET domain bifurcated 1,TDRD21,tudor domain containing 21.

Produktbeschreibung

Histone methyltransferase that specifically trimethylates Lys-9 of histone H3. H3 Lys-9 trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 Lys-9 trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone Lys-9 trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells (PubMed:24623306). Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) (PubMed:24623306). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing (PubMed:24623306). The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).

Produkteigenschaften

• Molekulargewicht: 71.7 kDa
• Tag: N-terminal GST-tagged
• NCBI: 9869
• Quelle: E.coli
• Reinheit: Greater than 90% as determined by SDS-PAGE.
• Formulierung: Liquid or Lyophilized powder
• Sequenz: Full Length of Isoform 2: MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKSAQDVQKFMDAVNKKSSSQDLHKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKK