aryl hydrocarbon hydroxylase,cholesterol 25-hydroxylase,CP12,CYPIA2,cytochrome P(3)450,cytochrome P450 1A2,cytochrome P450 4,cytochrome P450, family 1, subfamily A, polypeptide 2,cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2,cytochrome P450-P3,dioxin-inducible P3-450,flavoprotein-linked monooxygenase,hydroperoxy icosatetraenoate dehydratase,microsomal monooxygenase,P3-450,P450 form 4,P450(PA),xenobiotic monooxygenase.
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
