1,25- dihydroxyvitamin D3 24-hydroxylase,1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial,24-OHase,CP24,CYP24,cytochrome P450 24A1,cytochrome P450, family 24, subfamily A, polypeptide 1,cytochrome P450, subfamily XXIV (vitamin D 24-hydroxylase),cytochrome P450-CC24,exo-mitochondrial protein,HCAI,HCINF1,P450-CC24,vitamin D 24-hydroxylase,vitamin D(3) 24-hydroxylase.
Has a role in maintaining calcium homeostasis. Catalyzes the adrenodoxin-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.