CD121 antigen-like family member A,CD121A,D2S1473,IL1R,IL-1R-1,IL1RA,IL-1R-alpha,IL-1RT1,IL-1RT-1,interleukin 1 receptor alpha, type I,interleukin-1 receptor alpha,interleukin-1 receptor type 1,interleukin-1 receptor type I,P80.
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (PubMed:10653850).
