CD121,CD121 antigen-like family member A,CD121a,CD121b,I,IL-,Il1,IL-1 receptor alpha chain,Il1r-1,IL-1R1,IL-1R-1,IL-1R-alpha,IL-1RT1,IL-1RT-1,IL-iR,interleukin-1 receptor alpha,interleukin-1 receptor type 1,Interleukin-1 receptor type I,p80.
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity).
