DIRA,ICIL-1RA,IL1 inhibitor,IL1F3,IL-1ra,IL1RA,IL-1ra3,IL-1RN,interleukin-1 receptor antagonist protein,intracellular IL-1 receptor antagonist type II,intracellular interleukin-1 receptor antagonist (icIL-1ra),IRAP,MVCD4,type II interleukin-1 receptor antagonist.
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2, however, the physiological relevance of the latter association is unsure.
