AHUS2,antigen identified by monoclonal antibody TRA-2-10,CD46 antigen, complement regulatory protein,CD46 molecule, complement regulatory protein,complement membrane cofactor protein,MCP,measles virus receptor,membrane cofactor protein,membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen),MIC10,TLX,TRA2.10,trophoblast leucocyte common antigen,trophoblast leukocyte common antigen,trophoblast-lymphocyte cross-reactive antigen.
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.
