BIT,Brain Ig-like molecule with tyrosine-based activation motifs,brain-immunoglobulin-like molecule with tyrosine-based activation motifs,CD172 antigen-like family member A,CD172A,inhibitory receptor SHPS-1,macrophage fusion receptor,MFR,MYD-1,myd-1 antigen,P84,PTPNS1,SHPS1,Signal-regulatory protein alpha-1,Signal-regulatory protein alpha-2,Signal-regulatory protein alpha-3,SIRP,tyrosine phosphatase SHP substrate 1,tyrosine-protein phosphatase non-receptor type substrate 1.
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
