ALPS1A,APO-1,Apo-1 antigen,APO-1 cell surface antigen,apoptosis antigen 1,apoptosis signaling receptor FAS,apoptosis-mediating surface antigen FAS,APT1,CD95,CD95 antigen,Fas (TNF receptor superfamily, member 6),Fas AMA,FAS1,FASLG receptor,FASTM,mutant tumor necrosis receptor superfamily member 6,TNF receptor superfamily member 6,TNFRSF6,tumor necrosis factor receptor superfamily member 6,tumor necrosis factor receptor superfamily, member 6.
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
