ALPS1B,apoptosis (APO-1) antigen ligand 1,apoptosis antigen ligand,APT1LG1,APTL,CD178,CD95 ligand,CD95L,CD95-L,fas antigen ligand,Fas ligand (TNF superfamily, member 6),FASL,mutant tumor necrosis factor family member 6,TNFSF6,TNLG1A,tumor necrosis factor ligand 1A,tumor necrosis factor ligand superfamily member 6.
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260).
