Recombinant Human Platelet Factor-4 (CXCL4) Variant-1 Protein
Artikelnummer:
ASB-OPPA02067
Hersteller Artikelnummer:
OPPA02067
Alternativnummer:
ASB-OPPA02067-1UG
Hersteller:
Aviva
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Human
Alternative Synonym:
PF-4, CXCL4, SCYB4
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemocinfamily. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.
