JUNB antibody - C-terminal region (P100947_T100), Rabbit, Polyclonal
Artikelnummer:
ASB-P100947_T100
Hersteller Artikelnummer:
P100947_T100
Alternativnummer:
ASB-P100947_T100-100UL, ASB-P100947_T100-25UL
Hersteller:
Aviva
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
WB
Spezies Reaktivität:
Bovine, Canine, Guinea pig, Human, Mouse, Rat, Sheep, Zebrafish
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human JUNB
Alternative Synonym:
AP-1
The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation.
