oYo-Link VcMMAF Antibody Labeling Reagent - Labels 100ug

Produktübersicht

• Artikelname: oYo-Link VcMMAF Antibody Labeling Reagent - Labels 100ug
• Artikelnummer: ATR-AT7003-100
• Hersteller Artikelnummer: AT7003-100
• Alternativnummer: ATR-AT7003-100
• Hersteller: AlphaThera
• Kategorie: Antikörper
• Applikation: Cytotoxic Assay
• Konjugation: VcMMAF

Produktbeschreibung

Research Use Only Application: Antibody conjugation Reagent for Targeted cell death, Targeted cell death for cancer cells, High-throughput screening with cell killing assays oYo-Link VcMMAF is an Antibody-Drug Conjugation Reagent allowing for site-specific labeling of Monomethyl Auristatin F. labels to the heavy-chains of oYo-Link-compatible antibodies with up to two labels per antibody. VcMMAF is an anti-mitotic agent linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). oYo-Link limits the attachment of the VcMMAF drugs to the heavy chains of the antibody and therefore ensures that the drug label does not interfere with antibody binding. Furthermore, site-specific labeling limits 1-2 VcMMAF drugs to be attached per antibody, providing precise antibody-drug conjugate ratios. The antibody labeling procedure simply requires mixing oYo-Link VcMMAF with the desired antibody followed by photocrosslinking with non-damaging black light (365 nm). Photocrosslinking can be carried in most buffers, including those containing amine-containing molecules (e.g. TRIS, glycine) or storage proteins (see Buffer Compatibility Table). Catalog AT7003 Requirements: To label your compatible antibodies with oYo-Link, you will need a Light Source emitting at 365nm (6-10W). Use your own Compatible Device from our list or purchase AlphaTheras LED Photo-Crosslinking Device. Technical Support: For science questions or questions concerning compatibility email support alphathera.com

Produkteigenschaften

• Konzentration: 270 µg/mL
• Molekulargewicht: 8 kDa
• Puffer: PBS
• Formulierung: Dried pellet

Bilder

oYo-Link VcMMAF Product Icon

oYo-Link VcMMAF Chemical Structure

oYo-Link VcMMAF Photo-crosslinking Efficiency shown by SDS-PAGE

oYo-Link VcMMAF Cell Killing Assay for A431 Cells