Human IgD (Immunoglobulin Delta Heavy Chain) (B-Cell Marker) (IGHD/2730R), CF405S conjugate, 0.1mg/mL, Clone: [IGHD/2730R], Rabbit, Monoclonal

Produktübersicht

• Artikelname: Human IgD (Immunoglobulin Delta Heavy Chain) (B-Cell Marker) (IGHD/2730R), CF405S conjugate, 0.1mg/mL, Clone: [IGHD/2730R], Rabbit, Monoclonal
• Artikelnummer: BOT-BNC042730-500
• Hersteller Artikelnummer: BNC042730-500
• Alternativnummer: BOT-BNC042730-500-500UL
• Hersteller: Biotium
• Wirt: Rabbit
• Kategorie: Antikörper
• Spezies Reaktivität: Human
• Immunogen: Recombinant full-length human IGHD protein
• Konjugation: CF405S
• Alternative Synonym: Ig delta chain C region, IGHD, Immunoglobulin heavy constant delta

Produktbeschreibung

Immunoglobulins are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment and the Fc (constant) fragment. Immunoglobulin D (IgD) exists as a monomer withi´ heavy chains and either i or i light chains. It plays a biological role as a transmembrane receptor molecule, co-expressed with IgM on the surface of mature/naive B cells. In particular, it is found on spleen B cell surfaces. Compared to IgM, IgD exists in much lower numbers and is not expressed on immature B cells. IgD surface expression on B cells is regulated in part by IL-27. In mice, the inhibition of this immunoglobulin isotype does not cause a significant change to the immune system. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Produkteigenschaften

• Klonalität: Monoclonal
• Konzentration: 0.1 mg/mL
• Klon-Bezeichnung: [IGHD/2730R]
• Molekulargewicht: 44-80 kDa (heavy chain), 21-25 kDa (kappa light chain)
• UniProt: P01880
• Puffer: PBS, 0.1% BSA, 0.05% azide
• Quelle: Animal

Anwendungsbeschreibung

• Anwendungsbeschreibung: For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry