PD1, Mouse(RMP1-14), CF568 conjugate, 0.1mg/mL, Clone: [RMP1-14], Rat, Monoclonal
Artikelnummer:
BOT-BNC682002-500
Hersteller Artikelnummer:
BNC682002-500
Alternativnummer:
BOT-BNC682002-500-500UL
Hersteller:
Biotium
Wirt:
Rat
Kategorie:
Antikörper
Applikation:
FC, Functional Studies
Spezies Reaktivität:
Mouse
Immunogen:
PDCD1 transfected BHK cells
Konjugation:
CF568
Alternative Synonym:
CD279, CD279 antigen, PD1, PDCD1, Programmed cell death 1, Programmed cell death protein 1, Systemic lupus erythematosus susceptibility 2 (SLEB2)
PD-1 is expressed on a subset of CD4-CD8-thymocytes, and on activated T and B cells. PD-1 is thought to be involved in lymphocyte clonal selection and peripheral tolerance. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B-lymphocytes and myeloid cells. Additionally, Pdcd1mRNA is expressed in developing B-lymphocytes during the pro-B-cell stage. The RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production co-stimulated by macrophages (but not by dendritic cells and B cells). Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
