Recombinant human DR5 protein fragment (around aa266-393) (exact sequence is proprietary)
Konjugation:
CF568
Alternative Synonym:
Fas like protein, Apoptosis inducing protein TRICK2A/2B, Apoptosis inducing receptor TRAIL R2, Cytotoxic TRAIL receptor 2, Death domain containing receptor for TRAIL/Apo 2L, Death receptor 5 (DR5), p53 regulated DNA damage inducible cell death receptor (killer), TNF related apoptosis inducing ligand receptor 2 (TRICK2, Tumor necrosis factor receptor like protein ZTNFR9, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes Fas antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the death domain , that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including Fas, DR2 (or TRUNDD), DR3 (death receptor 3), DR4 and DR5. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor, designated decoy receptor (DcR1 or TRID), also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Klonalität:
Monoclonal
Konzentration:
0.1 mg/mL
Klon-Bezeichnung:
[DR5/3381]
Molekulargewicht:
48 kDa
UniProt:
521456
Puffer:
PBS, 0.1% BSA, 0.05% azide
Quelle:
Animal
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
