Human IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker)(IGHM/2557R), CF740 conjugate, 0.1mg/mL, Clone: [IGHM/2557R], CF 740, Rabbit, Monoclonal
Artikelnummer:
BOT-BNC742557-100
Hersteller Artikelnummer:
BNC742557-100
Alternativnummer:
BOT-BNC742557-100-100UL
Hersteller:
Biotium
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IHC
Spezies Reaktivität:
Human
Immunogen:
Heavy chain of human IgM
Konjugation:
CF 740
Alternative Synonym:
AGM1, IGHM, Constant Region of Heavy Chain of IgM, Ig Mu Chain C Region
Recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstroms macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
