DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), 0.2mg/mL

Produktübersicht

• Artikelname: DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), 0.2mg/mL
• Artikelnummer: BOT-BNUB1898-500
• Hersteller Artikelnummer: BNUB1898-500
• Alternativnummer: BOT-BNUB1898-500-500UL
• Hersteller: Biotium
• Kategorie: Antikörper
• Applikation: IHC-P

Produktbeschreibung

The specificity of this monoclonal antibody to its intended target was validated by HuProt(TM)Array, containing more than 19,000, full-length human proteins. DNMT3A is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated Lys-36 of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Produkteigenschaften

• Konzentration: 0.2 mg/mL
• Puffer: PBS, 0.05% BSA, 0.05% azide
• Quelle: Animal