CD40, Mouse(FGK45.5), 0.2mg/mL, Clone: [FGK45.5], Rat, Monoclonal
Artikelnummer:
BOT-BNUB2005-100
Hersteller Artikelnummer:
BNUB2005-100
Alternativnummer:
BOT-BNUB2005-100-100UL
Hersteller:
Biotium
Wirt:
Rat
Kategorie:
Antikörper
Applikation:
FC, Functional Studies
Spezies Reaktivität:
Mouse
Immunogen:
Purified recombinant Mouse CD40 fusion protein
Alternative Synonym:
B cell surface antigen CD40, CD40 type II isoform, p50, Bp50, CD40L receptor, CDW40, TRAP, IMD3, IGM, Tnfrsf5, HIGM1, GP39, T-BAM
Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4. 5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
