Recombinant human ITGAE protein fragment (exact sequence is proprietary)
Alternative Synonym:
CD103, Integrin alpha E, Integrin subunit alpha E
CD103 is alpha E integrin, belonging to a small beta-7 integrin subfamily. It is primarily expressed in intraepithelial lymphocytes. Together with beta 7 integrin, it is the cell surface receptor for E-cadherin, where it mediates cell adhesion. CD103 is expressed on more than 95% of intraepithelial CD8 cells and on 40% of mucosa-associated T cells, whereas less than 2% of resting blood lymphocytes are CD103-positive. In several malignant conditions, such as T-cell lymphomas and hairy cell leukemia (HCL), the cells express CD103. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunohistology (formalin): 1-2 ug/mL for 30 minutes at RT|Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes|Optimal dilution for a specific application should be determined by user
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