A recombinant fragment (around aa 19-188) of human CD137 / 4-1BB / TNFRSF9 protein (exact sequence is proprietary)
Alternative Synonym:
4-1BB Ligand Receptor T Cell, Antigen 4-1BB Homolog, CDw137, HLDA VI, Homolog of Mouse 4 1BB, induced by lymphocyte activation (ILA), Interleukin activated receptor homolog of Mouse Ly63, T-cell antigen 4-1BB / ILA homolog, Tumor necrosis factor receptor superfamily member 9
CD137 belongs to the tumor necrosis factor receptor family and delivers a costimulatory signal to T lymphocytes. It is expressed on activated T cells and binds an inducible ligand that is found on B cells, macrophages and dendritic cells. Interactions between CD137 and its ligand are involved in antigen presentation and the generation of cytotoxic T cells. CD137 antibody may improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
