Aurora B (Proliferation Marker)(rAURKB/1592), 1mg/mL

Produktübersicht

• Artikelname: Aurora B (Proliferation Marker)(rAURKB/1592), 1mg/mL
• Artikelnummer: BOT-BNUM3787-50
• Hersteller Artikelnummer: BNUM3787-50
• Alternativnummer: BOT-BNUM3787-50-50UL
• Hersteller: Biotium
• Kategorie: Antikörper
• Applikation: IHC-P
• Spezies Reaktivität: Mouse

Produktbeschreibung

This antibody recognizes a protein of 39 kDa, which is identified as Aurora kinase B (or Aurora B). Aurora B is a serine/threonine protein kinase and component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. It is important for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Produkteigenschaften

• Konzentration: 1 mg/mL
• Puffer: PBS, no BSA, no azide
• Quelle: Animal