presenilin 1 Polyclonal Antibody, PE Conjugated, Mouse
Artikelnummer:
BSS-BS-0024M-PE
Hersteller Artikelnummer:
bs-0024M-PE
Alternativnummer:
BSS-BS-0024M-PE-100
Hersteller:
Bioss
Wirt:
Mouse
Kategorie:
Antikörper
Applikation:
IF
Spezies Reaktivität:
Human, Mouse
Konjugation:
PE
Alternative Synonym:
Presenilin-1, PS-1, Protein S182, Psen1, Psnl1
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis (By similarity).
