Cyclin C Polyclonal Antibody, Biotin Conjugated, Rabbit
Artikelnummer:
BSS-BS-0282R-BIOTIN
Hersteller Artikelnummer:
bs-0282R-Biotin
Alternativnummer:
BSS-BS-0282R-BIOTIN-100
Hersteller:
Bioss
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
ELISA, IHC-Fr, IHC-P, WB
Spezies Reaktivität:
Human
Konjugation:
Biotin
Alternative Synonym:
CycC, Cyclin-C, SRB11 homolog, hSRB11, CCNC
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
