EC 3.5.3.15, HL 60 PAD, HL-60 PAD, PAD 4, PAD, PADI 4, PADI 5, PADI H protein, PADI5, PDI 4, PDI 5, PDI4, PDI5, Padi4, PADI4_HUMAN, Peptidyl arginine deiminase type IV, Peptidyl arginine deiminase type V, Peptidylarginine deiminase IV, Protein arginine deiminase, Protein-arginine deiminase type IV, Protein-arginine deiminase type-4, Protein arginine deiminase type 4, Protein arginine deiminase type IV.
PADI4 (peptidyl arginine deiminase, type IV) catalyzes the deimination of arginine residues of proteins. Down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. subcellular location at cytoplasmic granules. Belongs to the protein arginine deiminase family. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.
