MST3 (phospho T178), p-MST3 (phospho T178), Kinase responsive to stress 1, KRS1, Mammalian STE20 like protein kinase 2, Mammalian sterile 20-like 2, Mess1, MST, MST-2, MST2, Mst3, Serine/threonine kinase 3 (STE20 homolog, yeast), Serine/threonine kinase 3 (Ste20, yeast homolog), Serine/threonine protein kinase 3, Serine/threonine protein kinase Krs1, STE20 like kinase MST2.
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on Thr-442 and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.
