C11orf32, FLJ21930, FLJ39258, gp250, LDLR relative with 11 ligand binding repeats, LDLR relative with 11 ligand-binding repeats, Low density lipoprotein receptor relative with 11 ligand binding repeats, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LR 11, LR11, LRP 9, LRP9, Mosaic protein LR11, SORL 1, SORL_HUMAN, SORL1, SorLA 1, SorLA, SorLA-1, Sortilin related receptor, Sortilin related receptor LDLR class A repeats containing, Sortilin-related receptor, Sorting protein related receptor containing LDLR class A repeats, Sorting protein-related receptor containing LDLR class A repeats,
Sortilin-related receptor, also known as Sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL (the main cholesterol-carrying lipoprotein of plasma) and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP, receptor-associated protein. SorLa is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous sorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. It is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.
