ASRT2, G protein coupled receptor 154, G protein coupled receptor for asthma susceptibility, G protein coupled receptor PGR14, GPR 154, gpr154, GPRA, MVTR, Neuropeptide S receptor 1, Neuropeptide S receptor, nps receptor, NPSR 1, NPSR, NPSR1, PGR 14, PGR14, PGR-14, Vasopressin receptor related receptor 1, VRR 1, VRR1, NPSR1_HUMAN.
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR154 (G-protein coupled receptor 154), also known as NPSR1 (neuropeptide S receptor), GPRA (G-protein coupled receptor for asthma susceptibility) or PGR14, is a 371 amino acid protein that is thought to play a role in autocrine or paracrine signaling pathways. Ubiquitously expressed, GPR154 exists as nine alternatively spliced isoforms. Defects in the gene encoding GPR154 is the cause of asthma-related traits type 2 (ASRT2).
