61E3.4, ATX, hSMG1, KIAA0421, Lambda interacting protein, Lambda/iota protein kinase C interacting protein, LIP, Phosphatidylinositol 3 kinase related kinase, Phosphatidylinositol 3 kinase related protein kinase, PI-3-kinase-related kinase SMG-1, Serine/threonine protein kinase SMG1.
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]
