GAI3, 87U6, FLJ26559, G protein alpha inhibiting 3, Gi alpha 3, Gi alpha-3, GNAI3, GNAI3_HUMAN, Guanine nucleotide binding protein G protein alpha inhibiting activity polypeptide 3, Guanine nucleotide binding protein Gk alpha subunit, Guanine nucleotide-binding protein Gk subunit alpha, OTTHUMP00000013368, Gnai3, Guanine nucleotide binding protein G protein, alpha inhibiting 3, G Alpha i-3.
GAI3 is the a subunit of inhibitory trimeric G protein (Gi), which inhibits adenylate cyclase once its G protein coupled receptors (GPCR) such as a2 adrenergic receptors are activated. GAI3 can be inactivated by pertussis toxin. Guanine nucleotide binding proteins are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor regulated K(+) channels.
