C1orf22, EDEM 3, edem3, EDEM3_HUMAN, ER degradation enhancer, mannosidase alpha like 3, ER degradation enhancing alpha mannosidase like 3, ER degradation enhancing alpha mannosidase like 3, ER degradation-enhancing alpha-mannosidase-like 3.
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]
